{
  "id": "ctis:2026-525620-23-00",
  "euct": "2026-525620-23-00",
  "title": "Local and Systemic Immune Modulation by Rilvegostomig in Advanced Gastric Cancer: The RILVE Project",
  "publicTitle": "Local and Systemic Immune Modulation by Rilvegostomig in Advanced Gastric Cancer: The RILVE Project",
  "fullTitle": "Local and systemic immune modulation by Rilvegostomig (AZD2936) in the treatment of advanced gastric cancer (RILVE Project)",
  "shortTitle": "VHIO26001/ESR2523009",
  "status": "Authorised",
  "statusCode": "2",
  "startDateEU": null,
  "decisionDate": "2026-07-22T10:55:01.733",
  "publishDate": "2026-07-23T03:41:42.227820981",
  "trialRegion": "Both",
  "trialRegionCode": "3",
  "medicalConditions": [
    {
      "name": "advanced gastric cancer",
      "rareDisease": false
    }
  ],
  "therapeuticAreas": [
    {
      "code": "6",
      "name": "Diseases [C] - Digestive System Diseases [C06]"
    },
    {
      "code": "4",
      "name": "Diseases [C] - Neoplasms [C04]"
    }
  ],
  "trialCategory": {
    "phaseCode": "4",
    "categoryCode": "2",
    "lowIntervention": false
  },
  "duration": {
    "estimatedRecruitmentStartDate": "2026-06-01",
    "estimatedEndDate": "2030-06-01",
    "estimatedGlobalEndDate": "2030-06-01"
  },
  "countries": [
    {
      "name": "Spain",
      "publicStatusCode": "2",
      "firstDecisionDate": "2026-07-22T10:55:01.733",
      "lastDecisionDate": "2026-07-22T10:55:01.733",
      "history": [
        {
          "source": "application_country_status",
          "applicationBusinessKey": "IN",
          "applicationType": "INITIAL",
          "status": "Authorised",
          "trialStatus": "Authorised",
          "decision": "authorized",
          "assessmentOutcome": "acceptable",
          "assessmentOutcomeDate": "2026-07-20",
          "date": "2026-07-22",
          "reportingStatusCode": "Authorised",
          "applicationStatusCode": "Authorised"
        },
        {
          "source": "application_decision",
          "applicationBusinessKey": "IN",
          "applicationType": "INITIAL",
          "status": "Authorised",
          "trialStatus": "Authorised",
          "decision": "authorized",
          "assessmentOutcome": "acceptable",
          "eventType": "decision",
          "date": "2026-07-22T10:55:01.733",
          "isRMS": true
        }
      ]
    }
  ],
  "applications": [
    {
      "id": "application:2026-525620-23-00:in",
      "businessKey": "IN",
      "type": "INITIAL",
      "status": "Authorised",
      "trialStatus": "Authorised",
      "submissionDate": "2026-04-30",
      "decisionDate": "2026-07-22",
      "decisions": [
        {
          "mscName": "Spain",
          "decisionDate": "2026-07-22T10:55:01.733",
          "decision": "authorized",
          "assessmentOutcome": "acceptable",
          "eventType": "decision",
          "applicationType": "INITIAL",
          "isRMS": true
        }
      ],
      "countryStatuses": [
        {
          "countryName": "Spain",
          "mscName": "Spain",
          "trialStatus": "Authorised",
          "decision": "authorized",
          "decisionDate": "2026-07-22",
          "firstDecisionDate": "2026-07-22",
          "assessmentOutcome": "acceptable",
          "assessmentOutcomeDate": "2026-07-20",
          "reportingStatusCode": "Authorised",
          "applicationStatusCode": "Authorised"
        }
      ]
    }
  ],
  "evidence": [
    {
      "id": "evidence:c9c51035d7df7913aec02ce5",
      "path": "authorizedApplication.authorizedPartI.trialDetails.trialInformation.endPoint.secondaryEndPoints[4].endPoint",
      "term": "artificial intelligence",
      "snippet": "…expression and/or spatial distribution in the tumor microenvironment (eg, CD8, PD-L1, etc.) as measured by IHC and other assays including analytical methods (eg, digital pathology artificial intelligence)."
    }
  ],
  "official": {
    "retrieveUrl": "https://euclinicaltrials.eu/ctis-public-api/retrieve/2026-525620-23-00",
    "publicUrl": "https://euclinicaltrials.eu/ctis-public/view/2026-525620-23-00?lang=en"
  },
  "slug": "2026-525620-23-00",
  "firstObservedAt": "2026-07-23T11:19:41.794Z",
  "lastObservedAt": "2026-07-23T13:03:56.000Z",
  "dateModified": "2026-07-23",
  "materialFingerprint": "a7ed01c8586fbeb7b4d207fc2835d4f04142c671b822b893bc142827c05ca376"
}